O-β-N-acetil-D-glicosaminiltransferase (OGT): Passado e Presente na Busca por Inibidores de um Interessante Alvo Terapêutico

Resumo

One of the many glycosylation types that occurs in living organisms is the process of O-linked
β-N-acetylglucosamine modification (O-GlcNAcylation), which involves the addition of monosaccharide
units. This process acts as a sensor highly linked to the cellular nutritional influx through the hexosamine
biosynthetic pathway. Any dysregulation in the O-GlcNAcylation process can be associated with
pathological conditions such as diabetes, cancer, cardiovascular, and neurodegenerative diseases.
Therefore, OGT is a promising molecular target for new therapies. Currently, no drugs are available on
the market based on the OGT inhibition. In this review, we focus on the research progress in developing
OGT inhibitors highlighting the different classes and structural patterns of molecules reported by their
potential inhibitory activity