Estratégias para a Síntese de Análogos MonoHalogenados da Juglona: Desbloqueando o Potencial de Metodologias de Síntese Regioespecífica

Resumo

This review article presents an overview of the different methodologies developed for the synthesis of
monohalogenated analogues of juglone (1), which is a versatile structural scaffold with a wide range of
biological activities. The synthesis of these monohalogenated analogues is of great importance in organic
synthesis, especially for the pharmaceutical and agrochemical industries, as they are key intermediates in
the regiospecificity of synthetic routes for the production of analogues and derivatives of 1. This review
article presents the different regiospecific strategies used for the production of mono-chlorinated, monobrominated and mono-iodinated analogues of 1, in addition to highlighting their differences based on
melting point and crystallographic studies. In short, this article provides a valuable reference for researchers
in the area of organic synthesis who aim to develop innovative bioactive molecules.