Fontes Naturais e Sintéticas de derivados de 2,3-Dihidrobenzofuranos: Uma Abordagem Recente

Resumo

The 2,3-dihydrobenzofuran scaffold is a 2,3-hydroderivative of the class of benzofurans, which are heterocyclic compounds formed by the bond between a benzene ring and a furan, and it acts as an important metabolite as well as indole alkaloids. In the literature, this nucleus is much related to different biological activities, which makes it widely applicable in the pharmaceutical industry, especially in the anticancer and antibacterial fields. Thus, different drugs containing the dihydrobenzofuran core are commercialized. In this context, many scientists have been looking for different alternatives to obtain and/or modify them, with the last years focused on environmentally adequate methodologies. The present work presents the recent advances in the different ways of obtaining the 2,3-dihydrobenzofuran nucleus, either by direct or indirect synthesis, or by extraction of natural products.