AApeptídeos como uma Nova Classe de Peptidomiméticos Ativos: Planejamento, Síntese e Atividades Biológicas

Resumo

The development of new therapeutic agents based on peptides has undergone a revolution in the last decade with the emergence of peptidomimetics. Recently, a new class of peptidomimetic has been reported, the AApeptides. Compared to conventional peptides, AApeptides have high proteolytic and metabolic stability and have presented varied therapeutic applications. However, studies reporting the development of AApeptides in Brazil are still unknown. Thus, the aim of this article was to describe the planning,
synthesis and therapeutic application of this important class of peptidomimetics in the scientific literature. Thus, it is intended to encourage new researchers to develop activities in this area, as well as to discuss the current knowledge regarding the research of peptidomimetics as new generation therapeutic agents.