Therapeutic potential of quercetin based on nanotechnology: A review

Autores

  • Tamires Andrade da Silva Federal University of Alagoas
  • Julio Henrique Rodrigues Gomes Federal University of Alagoas
  • Laisa Carolina Gomes de Bulhões Federal University of Alagoas
  • Roberto Miguel dos Santos Neto Federal University of Alagoas
  • Irinaldo Diniz Basílio Junior Federal University of Alagoas
  • Maria Aline Barros Fidelis de Moura Federal University of Alagoas
  • Ticiano Gomes do Nascimento Federal University of Alagoas
  • Luciano Aparecido Meireles Grillo Federal University of Alagoas
  • Camila Braga Dornelas Federal University of Alagoas

Palavras-chave:

Flavonoids, Quercetin, Nanotechnology, Drug delivery system, Nanotherapeutics.

Resumo

Quercetin, a natural flavonoid, has attracted considerable interest in its numerous health benefits; nevertheless, some limitations restrict its oral use. Therefore, to improve its bioavailability, investigators are applying nanotechnology, specifically nanocarriers, to direct quercetin to specific sites of action. Studies indicate that cancer is the most investigated disease due to high mortality and poor prognosis around the world, and the antiproliferative and apoptotic effects in different types of neoplasia, including breast cancer, have been reported. The greatest interest has also been focused on inflammatory and cardiovascular diseases. Thus, this review outlines the most relevant development scenarios, highlighting studies using the delivery mechanisms, showing that the studies present promising results.

Biografia do Autor

Tamires Andrade da Silva, Federal University of Alagoas

Department of Pharmacy

Julio Henrique Rodrigues Gomes, Federal University of Alagoas

Department of Pharmacy

Laisa Carolina Gomes de Bulhões, Federal University of Alagoas

Department of Pharmacy

Roberto Miguel dos Santos Neto, Federal University of Alagoas

Department of Pharmacy

Irinaldo Diniz Basílio Junior, Federal University of Alagoas

Department of Pharmacy

Maria Aline Barros Fidelis de Moura, Federal University of Alagoas

Department of Pharmacy

Ticiano Gomes do Nascimento, Federal University of Alagoas

Department of Pharmacy

Luciano Aparecido Meireles Grillo, Federal University of Alagoas

Department of Pharmacy

Camila Braga Dornelas, Federal University of Alagoas

Department of Pharmacy

Publicado

06-09-2019