Chemical constituents from the leaves of Morus nigra L. (Moraceae) collected in Casa Nova, Bahia, Brazil

Resumo

Morus nigra L. belongs to the family Moraceae, and is popularly used for the treatment of diabetes, dyslipidemias, cardiovascular diseases and gout. The present work describes the isolation and identification of compounds isolated from the leaves of M. nigra. The phytochemical investigation of hexane phase from the leaves of this species allowed the identification of the steroid β-sitosterol (1), while the ethyl acetate phase led to the characterization of two glycosylated flavonoids, kaempferol-3-O-glycoside (2) and quercetin-3-O-glycoside (3). The compounds were identified by Nuclear Magnetic Resonance analysis 1D (1H and 13C NMR data) and 2D (1H-1H COSY, 1H-13C HSQC, 1H-13C HMBC), as well as through the comparison with literature data. Our findings showed that this species is a promising source of flavonoids and have high relationship with other Morus species, besides being a potential candidate for the investigation of pharmacological properties.