UM PROTOCOLO SIMPLES E EFICIENTE PARA A REAÇÃO DE KNOEVENAGEL DE BENZILIDENEMALONONITRILES E AVALIAÇÃO DA ATIVIDADE LARVICIDA EM AEDES AEGYPTI

Resumo

Mosquitoes in the genus Aedes are responsible for the four important human disease viruses, such as, dengue, yellow fever, chikungunya and Zika. Although important advances have emerged in the development of alternative measures for mosquito control, chemical insecticides still remain a vital part of integrated control programs. In this sense, a set of benzylidenemalononitriles were synthetized in very good yields (99-71%), using only water and glycerol at temperature room. A comparative study of the larvicidal activity between benzylidenemalononitriles showed that the 2g (R= 4-Cl) compounds possess much better larvicidal activity (LC50 and LC90 of 9.42 and 15.02, respectively at 24h). Study of molecular docking was applied to identify the mode iteration of compound 2g with binding site at the enzyme acetylcholinesterase, the profile of interaction showed a score 48.9795, with five bonds in three different amino acids.